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Seven decades of US regime change efforts: What have they achieved?

More than seven decades after the United States helped to overthrow Iranโ€™s elected prime minister, Mohammad Mosaddegh, in 1953, the two countries are again locking horns. The ongoing war between Wasโ€ฆ

Seven decades of US regime change efforts: What have they achieved?
Al Jazeera โ€” 19 August 2026
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More than seven decades after the United States helped to overthrow Iranโ€™s elected prime minister, Mohammad Mosaddegh, in 1953, the two countries are again locking horns.

The ongoing war between Washington and Tehran began when the US and Israel launched strikes across Iran on February 28, claiming Tehran was on the cusp of acquiring nuclear weapons.

The war has been marked by fighting across the region, including Iranian retaliatory attacks on Gulf states. The conflict has also spilled into Lebanon, where Israel says it is targeting strongholds of the Iran-backed group Hezbollah, and Yemen, where the Iran-backed Houthis are currently targeting Saudi-linked ships in the Red Sea. The conflict has upended global energy markets, with the closure of the critical Strait of Hormuz, and progress towards a peace deal has stalled.

The US-Israel war on Iran is just the latest chapter in a US-Iran relationship that has been shaped by coups, covert operations, sanctions, military confrontations and brief, yet unsuccessful, attempts at diplomacy.

Since Iranโ€™s 1979 Islamic revolution, led by former Supreme Leader Ruhollah Khomeini, overthrew the US-backed Shah Mohammed Reza Pahlavi, Washington has repeatedly sought to weaken the government in Tehran.

However, Iran is not an isolated case. From Guatemala and Cuba to Chile and Venezuela, the US has repeatedly intervened over the years against governments it considered hostile to its interests.

What have those efforts resulted in โ€“ and what lessons might they hold for Washington now?

In 1953, the USโ€™s Central Intelligence Agency (CIA) worked with Britain to overthrow Iranโ€™s democratically elected Prime Minister Mohammad Mosaddegh after he nationalised the Anglo-Iranian Oil Company, something the Western powers saw as going against their interests. Mosaddegh had been in power since 1951.

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